Speakers

Biography

Dr. S. Daoui is a distinguished figure in the field of chemistry, known for his contributions to applied chemistry and environmental science. Iam currently serves as a researcher at the Laboratory of Applied Chemistry and Environment, situated at Mohamed I University in Oujda, Morocco.

Abstract

The starting compounds 6- (styryl) -4,5-dihydropyridazinones 4, used for the condensation, alkylation and alkaline hydrolysis reaction, were prepared from levulinic acid 1 according to Scheme 1. The treatment of compound 1 with the aromatic compound aldehydes 2 produced intermediate benzylidenelevevulinic acid 3. The resulting derivatives 3 were then treated with hydrazine hydrate in regenerating acetic acid to obtain the desired styrylpyridazinones 4.Scheme 2 describes the synthesis of compounds 5, 6, 7 as follows: the new compounds were synthesized by condensation of pyridazinone derivatives with the appropriate aromatic aldehyde 2 in the presence of sodium methanoate. The compounds 5, in turn, were alkylated with ethyl bromoacetate to give the esters. The alkaline hydrolysis of the compounds 6 gave the new carboxylic acids 7.

The 3 (2H) -pyridazinones are the pyridazine derivatives containing two nitrogen atoms adjacent to positions 1 and 2 in a six-membered ring and a carbonyl group in third position and they have different functionalities in their structure Several studies have been oriented towards the organic synthesis of pyridazines. These heterocyclic nitrogen compounds are of biological importance and therefore the design and strategy of their synthesis is important. In addition, it has been proven that different pyridazinone products are known for their intense biological activity.