Excessive use of chemicals to control plant diseases negatively impacts the environment, prompting the need for sustainable alternatives. This study demonstrates that foliar application of aqueous leaf extracts from Argemone mexicana, Eucalyptus globulus, Bassia scoparia, Mallotus philippensis, and Shorea robusta, followed by challenge inoculation with Xanthomonas oryzae pv. oryzae (Xoo), effectively induces systemic resistance in rice. Treated plants showed significantly reduced bacterial blight incidence and higher chlorophyll A fluorescence, indicating PSII protection. Antioxidant enzymes (GPx, CAT, SOD, GR) and total protein levels were elevated, particularly on the 6th and 9th days, while MDA levels were reduced. Enhanced resistance was further supported by increased phenols, tannins, and flavonoids in extracts (except A. mexicana) and confirmed via DPPH scavenging activity. These findings highlight the potential of plant extracts as eco-friendly inducers of disease resistance in rice