Village Hotel Changi, Singapore
3rd Edition Of Plant Science and Molecular Biology World Conference 2026
Speakers - PMBWC2025
Fatma Bendimerad Mouttas
- Designation: Department of Biology, Abou Bekr Belkaïd University
- Country: Algeria
- Title: Bioactive Compounds From Rhaponticum Acaule (L.) DC Flower: Study of Their Anticancer Activity of Organic Extracts and Their RP HPLC PDA Analysis
Abstract
Rhaponticum acaule (L.) DC. is a medicinal plant commonly used in region of Tlemcen from northwestern Algeria for the treatment of some illness such as gastrointestinal infections, treatment of fever and other affections. In this work, we have tested the antiproliferative effect of R.acaule extracts on the lines of 4T1 and AMB-231 cells. And there, RP-HPLC-PDA analysis. The results obtained from the study of the anticancer activity showed a reduction in breast cancer cell proliferation in a dose-dependent manner, with an IC50 ranging from 13.33µg/ml to 11.61µg/ml. Of capitula methanolic extract on cell proliferation of the two lines 4T1 and AMB-231. The RP-HPLC-PDA analysis revealed that there are five phenolic acids, including sinapic, caffeic, chlorogenic, ferulic, and syringic acids, one flavanone; naringenin), and one flavonol; rutin and vanillin compound.
Keywords: Rhaponticum acaule, Médicinal plants, Phenolic compounds, Anticancer activity, RP-HPLC-PDA, Cell proliferation,
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