Speakers - PMBWC2025

Biography

Fatma Bendimerad is an accomplished biologist with extensive academic and professional experience. She earned her Diploma of Higher Studies (D.E.S) in Biology, specializing in Biochemistry, in 1993, followed by a Master's in Food and Nutrition in 2014 and a Doctorate in Nutrition and Health in 2021. Fluent in both French and English, Fatma has held several key positions at the University of Tlemcen. She served as the Head of the educational laboratory in Biochemistry and Biophysics from 2004 to 2010 and later transitioned to the Hemobiology and Immunology laboratory until 2013. Currently, she is on secondment to the Plant Biology laboratory while also working as a research laboratory attaché in General Surgery under Professor Belkalfat. Additionally, she has contributed as an assistant in practical animal biology from 2016 to 2023, demonstrating her dedication to both research and education in the field of biology.

Abstract

Rhaponticum acaule (L.) DC. is a medicinal plant commonly used in region of Tlemcen from northwestern Algeria for the treatment of some illness such as gastrointestinal infections, treatment of fever and other affections. In this work, we have tested the antiproliferative effect of R.acaule extracts on the lines of 4T1 and AMB-231 cells. And there, RP-HPLC-PDA analysis. The results obtained from the study of the anticancer activity showed a reduction in breast cancer cell proliferation in a dose-dependent manner, with an IC50 ranging from 13.33µg/ml to 11.61µg/ml. Of capitula methanolic extract on cell proliferation of the two lines 4T1 and AMB-231. The RP-HPLC-PDA analysis revealed that there are five phenolic acids, including sinapic, caffeic, chlorogenic, ferulic, and syringic acids, one flavanone; naringenin), and one flavonol; rutin and vanillin compound.

Keywords: Rhaponticum acaule, Médicinal plants, Phenolic compounds, Anticancer activity, RP-HPLC-PDA, Cell proliferation,